Assessment of Predictive Power for Fluid Responsiveness of Rainbow Pleth Variability Index in Children
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 45
- 主要终点
- AUC of ROC curve
研究概览
简要总结
The purpose of this study is to validate Rainbow pleth variability index for prediction of fluid responsiveness in children.
详细描述
Children undergoing surgery under general anesthesia will be enrolled. After anesthetic induction, they will be assessed via transthoracic echocardiography for measurement of the patient's stroke volume index (SVI). Also, pleth variability index and Rainbow pleth variability index will be measured under mechanical ventilation with tidal volume of 6, 8, 10 ml/kg.
To exert fluid loading, 10ml/kg of crystalloid solution will be administered intravenously over 10 minutes. After fluid loading, the SVI will be measured again and fluid responsiveness will be determined according to increment ratio of the SVI.
According to the determined fluid responsiveness, predictive power of pleth variability index and Rainbow pleth variability index for fluid responsiveness will be assessed by building a receiver-operating characteristics curve.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- — 至 6 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children undergoing neurosurgery under general anesthesia
排除标准
- •Presence of any cardiovascular disease
- •Presence of any pulmonary disease
- •Decline of enrollment from any of the patient's parents
结局指标
主要结局
AUC of ROC curve
时间窗: From start of anesthesia to end of anesthesia, Less than 24 hours
Area under the curve of the receiver-operating characteristics curve of pleth variability index and Rainbow pleth variability index for prediction of fluid responsiveness
次要结局
- SpO2(From start of anesthesia to end of study, Less than 24 hours)
- Appearance of abnormal heart rhythm(From start of anesthesia to end of study, Less than 24 hours)
- IBP(From start of anesthesia to end of study, Less than 24 hours)
研究者
Hee-Soo Kim
Professor
Seoul National University Hospital