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临床试验/NCT03416088
NCT03416088已完成不适用

The Influence of Daily Activities on Retinal Microcirculation in Normal Adults

Jiannan Huang1 个研究点 分布在 1 个国家目标入组 54 人开始时间: 2017年5月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
54
试验地点
1
主要终点
Vessel area density (VAD)

研究概览

简要总结

The daily behaviors such as drinking coffee, wine, reading, exercise and body postural changes may have influence on the function or morphology of the retinal microcirculation in healthy people.A recent study found that the fingertips microvascular bed constricted obviously after the intake of a cup of coffee with caffeine, it significantly reduced blood flow to the fingers; Long reading of electronic products can induce significant dry eye symptoms, affect visual quality, and cause asthenopia. Microcirculation is critical for regulating vascular resistance and blood flow in organs. Fundus blood vessels is the only visible microvascular in vivo, its morphology and function changes not only associated with eye disease, but also with cardiovascular and cerebrovascular diseases. Optical coherence tomography angiography (OCTA) is a new technique which could acquire blood flow information in a non-invasive way without the use of dye. Magnetic resonance imaging (MRI) can quantitatively evaluation of cerebral blood flow and retina-choroid blood flow using the noninvasive arterial spin labeling technique in a large field of view (FOV) without depth limitations.The study tried to detect the influence of daily behaviors such as drinking coffee, red wine, reading , exercise, etc. on the retinal microcirculation with OCTA and MRI, and provide reference for health behaviors.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Single (Outcomes Assessor)

盲法说明

Data analyzers are blind to the participants classification

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Healthy adults
  • •The age range was from 18 to 35 years old
  • •Without another eye disease besides ametropia
  • •The spherical equivalent is equal or above minus 3.00 diopters
  • •No smoking or drinking
  • •Average daily caffeine consumption no more than 1 cup of coffee
  • •No diabetes, hypertension, heart disease, liver or kidney dysfunction
  • •No medication taken recently

排除标准

  • •Mental disorders such as depression and anxiety
  • •Intellectual disabilities
  • •Female in menstruation, gestation period, perinatal period or lactation period
  • •Unable to cooperate with eye examinations and test procedures
  • •Heart disease, hypertension, diabetes, liver and kidney dysfunction and other chronic diseases
  • •Patients with fever, acute infectious diseases
  • •Other conditions that are not suitable for drinking alcohol or coffee, such as allergic to alcohol or coffee

研究组 & 干预措施

Body motion

Experimental

Exercise and body postural changes.

干预措施: Body motion (Behavioral)

Beverage consumption

Experimental

Drink 300ml red wine (alcohol concentration:12.5%), 300ml coffee (caffeine concentration 72 mg), 300 ml Baijiu (Chinese liquor, alcohol concentration:12.5%) , SipSparkTM Probiotics (facilitates ethanol degradation) was taken 0.5 hour prior to Baijiu consumption, or 300ml water.

干预措施: Beverage consumption (Behavioral)

Daily reading

Experimental

Reading paper books, playing video games with mobile phones, or non-reading.

干预措施: Daily reading (Behavioral)

结局指标

主要结局

Vessel area density (VAD)

时间窗: 3 weeks

VAD is calculated as a unit-less ratio of the total image area occupied by the vasculature to the total image area in the binary vessel maps.

Cerebral blood flow (CBF)

时间窗: 3 weeks

The frontal lobe was selected as the region of interest (ROI) to measure and average the changes in CBF

Vessel diameter index (VDI)

时间窗: 3 weeks

VDI is calculated using both the vessel area map and the skeletonized vessel map, to yield the averaged vessel caliber.

Flow impairment region (FIR)

时间窗: 3 weeks

FIZ: calculated by summing all 'no-flow' pixels up.

Retina-choroid blood flow

时间窗: 3 weeks

Blood flow for the entire retinal thickness were determined as a function of the distance from the optic nerve head, where the blood flow was measured at the peaks of the projection profiles. An region of interest outlining the posterior retina with a size of 0.7 to 0.8 mm across the retina-choroid thickness in the parafoveal region was used to obtain the blood flow signal time courses and averaged the values.

次要结局

未报告次要终点

研究者

发起方
Jiannan Huang
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Jiannan Huang

Director

Shanghai Eye Disease Prevention and Treatment Center

研究点 (1)

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