Study of Words Generation in Compulsives Gamblers and Healthy Volunteers: Comparison With a Study of Parkinson's Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- Changement of number of mistake during the words generation test
研究概览
简要总结
The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system.
Thanks to the words generation test, which reflects the cortico-subcortical loop functioning, involved in motivation, we want to evaluate and compare using tools (words generation and behavioral tests) the motivational functioning of gamblers and healthy volunteers that we can then compare to that of Parkinson's patients with and without behavioral hyperdopaminergic disorders which were explored in another study.
详细描述
The main objective of this study is to evaluate performance during words generation in gamblers and healthy volunteers compare to those of PD patients with and without hyper-dopaminergic behaviors collected during another study.
2 groups of subjects will be recruited for the study: 20 compulsive gamblers and 20 healthy volunteers
Each subject will realize twice each test during 2 sessions with one hour in between :
During the session 1 :
- The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.
- The test of Stroop that assesses selective attention
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For healthy volunteers :
- •Subject from 30 to 75 years old (Male and female)
- •Subject with French mother tongue
- •Subject who give their informed and signed consent.
- •Subject affiliated to a social protection program
- •For compulsive gamblers :
- •Subject from 30 to 75 years old (Male and female)
- •Subject with French mother tongue
- •Subject with at least 5 criteria of 10 DSM IV diagnostic criteria for pathological gambling
- •Subject who give their informed and signed consent.
- •Subject affiliated to a social protection program
排除标准
- •For healthy volunteers and compulsive gamblers :
- •Presence of apathy defined as a score greater or equal to 14 on the scale of Starkstein
- •Presence of severe depression defined as a score greater or equal to 25 on the scale BDI (Beck Depression Inventory)
- •Presence of dementia defined as a score below 25 on the MMSE
- •Subject with vision problems making it impossible for the tests
- •Pregnant women
- •Subject under tutelage, curatelle or law protection
- •Subject included in an other clinical study
结局指标
主要结局
Changement of number of mistake during the words generation test
时间窗: one hour
次要结局
- changement of number of uncorrected errors during the Stroop test which reflects the incapacity to inhibit the reading and that evaluates attention(one hour)