Potential Influences of Respiration Patterns on Experimental Pain Sensitization
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Area of Hypersensitivity surrounding the primary stimulation site
研究概览
简要总结
The goal of this clinical trial is to investigate the effect of breathing on the processing of experimental pain in healthy participants. The main questions are:
- Does breathing rate influence the spatial extent of thermally induced secondary hyperalgesia, a proxy of central sensitization?
- Does resonance frequency breathing influence the autonomic nervous system, compared to baseline and compared to paced breathing at a natural frequency?
- Is spinal excitability, measured using the magnitude of the nociception withdrawal reflex (NWR), affected by resonance frequency breathing, compared to paced breathing at a natural frequency?
Participants:
- will receive heat stimuli
- 's skin's sensitivity will be tested using quantitative sensory testing tools.
- will receive various instructions on the speed of their breathing
- 's heart rate, respiratory rate and sweat response will be measured
- will fill in questionnaires
Researchers will compare the spatial extent of sensitivity resulting from application of heat stimuli during paced resonance frequency breathing compared to paced breathing at a natural frequency to see if the breathing rhythm influences central sensitization processes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •over 18 and below 40 years of age
- •good general health
- •able to give informed consent
排除标准
- •any major medical or psychiatric condition (e.g. heart disease, diabetes, autoimmune disorders, infectious diseases, major depressive disorder), any chronic pain condition, any respiratory problems, any current acute pain at time of study
- •inability to follow study instructions, e.g. due to language problems
- •Consumption of alcohol, drugs, analgesics within the last 24 h
- •Consumption of no more than 100 mg of caffeine within the last 8 h
- •Scar tissue or generally reduced sensitivity in the designated testing site areas
- •Additional exclusion criteria for experiments 3 and 4
- •Shoe size < 38
- •Restless-Legs-Syndrome
结局指标
主要结局
Area of Hypersensitivity surrounding the primary stimulation site
时间窗: 40 minutes
Before and after thermal stimulations, the sensitivity of the skin is tested using a von Frey Filament, a Pin Prick and a brush. Thermal stimulations cause hypersensitivity of the skin, resulting in an area of hypersensitivity surrounding the stimulation site. The primary outcome measure is the amount of change in the area of hypersensitivity from before to after the thermal stimulations. The measuring unit of this outcome is square centimetres.
次要结局
- Root Mean Square of Successive Differences of the Heart Rate Variability(25 minutes)
- Galvanic Skin Potential(25 minutes)
- Threshold and Magnitude of the Nociceptive Withdrawal Reflex(25 minutes)
- Power in the Low-frequency Range of the Heart Rate Variability(25 minutes)
研究者
Schweinhardt Petra
Prof. Dr. med
Balgrist University Hospital