Can Shorter Time Intervals Help the Baby Survive the Triad Effect of Maternal Hypertension, Caesarean Section and Spinal Anesthesia?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- umbilical cord Ph
研究概览
简要总结
Patients were classified into two equal groups using the presence or absence of hypertension during pregnancy into: hypertensive group (BP>140/90) and normotensive group (BP≤140/90. The surgical time intervals are assessed and classified the patients accordingly into short and log time interval subgroups (induction of regional anesthesia to delivery (I-D), initial skin incision to delivery (S-D), and uterine incision to delivery (U-D)
详细描述
Surgical times components; induction of regional anesthesia till delivery (I-D interval); incision of the skin till delivery (S-D interval); and incision of the uterus till delivery (U-D interval)) were recorded using a stopwatch.
Immediately after delivery, umbilical cords were clamped on both ends and an arterial blood sample was collected anaerobically in a pre-heparinized insulin syringe. PH, base excess (BE), carbon dioxide pressure (PCO2), Oxygen pressure (PO2) and Bicarbonate (HCO3) levels were measured at 37oC by pH and gas analyzer (Gem, Premier3000, USA). The gas analysis was done in less than 30 minutes after sampling.
Apgar score was assessed by a neonatologist at the 1st and 5th minutes after birth . Advanced resuscitation included positive pressure ventilation, chest compression and/or drugs administration. All resuscitated babies were transferred to neonatal intensive care unit for post resuscitation care. Fetal distress was defined by an umbilical cord pH <7.12
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •full term pregnancy
- •singleton pregnancy
- •no medical disorders except hypertension in group 2
排除标准
- •Multiple pregnancies
- •complicated pre-eclamptic cases as placental abruption, eclampsia or HELLP syndrome,
- •preterm pregnancies,
- •true knots of the cord
- •reduced liquor,
- •in labour patients,
- •fetal distress
- •infants with major congenital malformations
研究组 & 干预措施
normal pregnancy
women at full term healthy pregnancy who underwent elective Cesarean section
干预措施: Cesarean section (Procedure)
pregnancy hypertension
women at full term pregnancy associated with hypertension who underwent elective Cesarean section
干预措施: Cesarean section (Procedure)
结局指标
主要结局
umbilical cord Ph
时间窗: immediately after delivery
umbilical cords were clamped on both ends and an arterial blood sample was collected anaerobically in a pre-heparinized insulin syringe
次要结局
- Apgar score(1 and 5 minutes after delivery)