NCT02863757招募中不适用
Disease Progression and Clinical Outcomes in Chronic Hepatitis B (CHB) Patients With Comorbid Nonalcoholic Fatty Liver Disease (NAFLD)
Humanity and Health Research Centre1 个研究点 分布在 1 个国家目标入组 1,500 人开始时间: 2016年8月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- Number of patients with liver cirrhosis, hepatic encephalopathy, esophageal varices, ascites and hepatocellular carcinoma
研究概览
简要总结
The purpose of this study is to determine the disease progression in CHB/NAFLD compared with CHB and NAFLD including liver cirrhosis, cirrhotic complications and hepatocellular carcinoma (HCC).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Liver biopsy proved CHB and/or NAFLD at baseline;
- •Follow-up duration>12 months
排除标准
- •Other liver diseases;
- •Secondary causes of hepatic steatosis;
- •Alcohol abuse;
- •Liver cirrhosis, cirrhosis related complications or HCC at baseline;
- •Malignancy;
- •History of liver transplantation
研究组 & 干预措施
CHB Group
Patients with chronic hepatitis B
CHB/NAFLD Group
Patients with chronic hepatitis B and comorbid nonalcoholic fatty liver disease
NAFLD Group
Patients with nonalcoholic fatty liver disease
结局指标
主要结局
Number of patients with liver cirrhosis, hepatic encephalopathy, esophageal varices, ascites and hepatocellular carcinoma
时间窗: Up to 20 years
次要结局
- Number of patients with hypertension, obesity, diabetes mellitus, hyperlipidaemia(Up to 20 years)
- Number of patients with liver transplantation and liver-related death(Up to 20 years)
- Diagnosis time of liver cirrhosis, hepatic encephalopathy, esophageal varices, ascites and hepatocellular carcinoma from baseline(Up to 20 years)
- Occurrence time of liver transplantation and liver-related death from baseline(Up to 20 years)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
ong-term clinical outcome of chronic hepatitis B naive patients treated with entecavir and tenofovir in KoreaCertain infectious and parasitic diseasesKCT0008111Hallym University Medical Center-Dongtan2,000
已完成
不适用
The Role of Biomarkers and Echocardiography in Prediction of Prognosis of Chronic Heart Failure PatientsHeart FailureNCT01851538Erasmus Medical Center398
进行中（未招募）
不适用
Prospective Observational Study of Disease Progression in Chronic Hepatitis CHepatitis C, ChronicDisease ProgressionLiver CirrhosisNCT02011932Beijing YouAn Hospital133
招募中
不适用
Long-Term Follow-up Study for Subjects With CHB Previously Treated With Imdusiran (AB729)Long Term Follow-upNCT06277037Arbutus Biopharma Corporation50
Unknown
不适用
Pronostic Factors of Long Term Outcome in Patients With Clubfoot Treated by the Ponseti MethodClubfootNCT04693065Hospices Civils de Lyon100