The Genetics Behind Vitamin D Status (VitDgen)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 102
- 试验地点
- 2
- 主要终点
- serum 25-hydroxyvitamin D
研究概览
简要总结
The overall purpose of the study is to investigate whether there is a relationship between 26 different single nucleotide polymorphisms (SNPs) in the vitamin D pathway, ultraviolet B (UV-B) irradiation of the skin and vitamin D status.
The hypothesis is that vitamin D status are influated by different genetic genotypes in the vitamin D pathway.
详细描述
In this study approximately 80 participants (over 18 years) are included. All the participants has previously participated in the VitmaD intervention study (NCT01184716) .
Participants will in total receive 4 times UV-B irradiation (3 SED) with two day apart each time, to stimulate vitamin D production in the skin. The participants skintype will be measured. The study starts in January 2013 and runs to the end of Marts 2013. During this winter period, it is in Denmark not possible to produce vitamin D in the skin through sunlight exposure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Health participants over 18 years, that previously participated in VitmaD intervention study
排除标准
- •skindiseases
- •intake of medicin that causes photosensitive skin
- •pregnant or nursing
- •sun vacation 3 month before the intervention
- •intake of vitamin D supplement 3 month before the intervention
研究组 & 干预措施
UV-B irraditation
VitDgen
干预措施: VitDgen (Genetic)
结局指标
主要结局
serum 25-hydroxyvitamin D
时间窗: 10 days
Measures the vitamin D status i serum at baseline and at the end of the project
次要结局
- Skintest(10 days)
研究者
Lone Banke Rasmussen
M.Sc., Ph.D.
Technical University of Denmark