NCT07138638尚未招募不适用
High-Frequency QRS for Predicting Microvascular Dysfunction and Adverse Events After PCI in Acute Myocardial Infarction: A Prospective, Multicenter Cohort Study
The Affiliated Hospital of Xuzhou Medical University1 个研究点 分布在 1 个国家目标入组 1,112 人开始时间: 2025年8月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 1,112
- 试验地点
- 1
- 主要终点
- To evaluate the predictive value of high-frequency QRS (HF-QRS) parameters for major adverse cardiovascular events (MACE) within 1 year after PCI in AMI patients and to construct a prognostic risk prediction model.
研究概览
简要总结
This observational study aimed to investigate the prognostic value of high-frequency QRS (HF-QRS) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI), as well as its potential role in diagnosing microvascular dysfunction. The main question it aims to answer is:
- Whether HF-QRS could serve as an effective tool for early identification of high-risk AMI patients and prognosis prediction;
- Whether HF-QRS provides auxiliary diagnostic value for post-AMI microvascular dysfunction.
Participants underwent HF-QRS assessment and were prospectively followed for 1 year to record the incidence of major adverse cardiovascular events (MACE).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18 to 75 years (inclusive)
- •Diagnosed with acute myocardial infarction (AMI, including STEMI and NSTEMI) and underwent successful emergency PCI
- •Voluntarily participated and provided written informed consent
排除标准
- •History of prior myocardial infarction or chronic heart failure
- •QRS duration >120 ms (including paced rhythm, WPW syndrome, bundle branch block, or left ventricular hypertrophy with repolarization abnormalities)
- •Structural heart disease (congenital heart disease, cardiomyopathy, aortic dissection, etc.)
- •Persistent atrial fibrillation or malignant arrhythmias
- •History of cerebral hemorrhage or ischemic stroke within 1 month
- •Prolonged cardiopulmonary resuscitation or requiring advanced life support (IABP/ECMO, etc.)
- •Scheduled for imminent surgery with anticipated inability to complete HF-QRS assessment
- •Other life-threatening conditions including: Severe hepatic or renal dysfunction;Uncontrolled systemic diseases;Hematologic disorders;Active infections;Malignancy with life expectancy <1 year Other investigator-determined exclusionary conditions:Pregnancy;Concurrent participation in other clinical trials
- •Refusal to participate in the clinical study
结局指标
主要结局
To evaluate the predictive value of high-frequency QRS (HF-QRS) parameters for major adverse cardiovascular events (MACE) within 1 year after PCI in AMI patients and to construct a prognostic risk prediction model.
时间窗: 12 months
次要结局
- To evaluate the adjunctive diagnostic value of high-frequency QRS parameters for microvascular dysfunction in ACS patients following percutaneous coronary intervention(12 months)
研究者
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
Risk Stratification Via HF-QRS and Fibrosis Biomarkers in Heart FailureHeart FailureNCT06959186The First Affiliated Hospital of Bengbu Medical University1,500
已完成
不适用
Early Prediction of QFR in STEMI-IST Segment Elevation Myocardial InfarctionNCT03780335RenJi Hospital162
Unknown
不适用
Early Prediction of QFR in STEMI-Pharmaco-invasiceST Segment Elevation Myocardial InfarctionNCT04220736RenJi Hospital200
已完成
不适用
Usefulness of High-frequency QRS Analysis in the Evaluation of Patients With Chest PainAcute Coronary SyndromeChest PainUnstable AnginaNSTEMISTEMINCT01185899Ori Galante324
Unknown
不适用
The Usefulness of HyperQ Recordings for the Early Diagnosis of Acute Coronary Syndrome in Patients Presenting With Chest PainAcute Coronary SyndromeNCT00339105Sheba Medical Center50