Testing the Effects of Individualized and 4mA tDCS
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Change in Motor Evoked Potential Variance
研究概览
简要总结
Transcranial direct current stimulation (tDCS) is a noninvasive method of modulating brain activity and has therapeutic potential in many neurological and psychiatric conditions. However, unlike every current FDA-approved form of brain stimulation, there is no method of individualizing stimulation dose. In this study, a method of individualizing tDCS dose on behavioral outcomes and whether this could help to improve the consistency and magnitude of the stimulation effects will be tested.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers or chronic stroke participants (at least 6 months prior to the study)
- •No history of epilepsy
- •No metal in the body
- •No contraindications for TMS or MRI scanning
- •Right handed
- •Ability to find motor hotspot and acquire motor evoked potentials
排除标准
- •Metal in the body
- •History of epilepsy or claustrophobia
- •Alcohol or substance abuse or dependence
- •Current treatment for any psychiatric conditions (pharmacological or otherwise)
- •Pregnant or actively breastfeeding
结局指标
主要结局
Change in Motor Evoked Potential Variance
时间窗: Baseline and post-stimulation (20 minutes apart)
MEP variance is measured by single pulses of transcranial magnetic stimulation and contralateral hand electrodes.
Difference in Motor Evoked Potential Amplitudes from 4mA and 2mA Stimulation
时间窗: Baseline and post-stimulation (20 minutes apart)
MEP amplitude is measured by single pulses of transcranial magnetic stimulation and contralateral hand electrodes.
次要结局
未报告次要终点
研究者
Kevin Caulfield
Research Assistant Professor-Faculty
Medical University of South Carolina