Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Change in blood lipids (Total cholesterol, HDL-Cholesterol, Triglycerides)
研究概览
简要总结
The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors.
详细描述
The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors. To do so, the metabolic risk factor response to an n-e PUFA supplementation will be compared in carriers and non-carriers of polymorphism within genes acting as fatty acids sensors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy men and women aged between 18 to 50 years;
- •having a BMI between 25 and 40kg/m2;
- •plasma triglycerides levels <4.0 mmol/L;
- •non-smokers;
- •free of any thyroid or metabolic disorders requiring treatment such as diabetes, hypertension, severe dyslipidemia, and coronary heart disease.
排除标准
- •subjects taking medication for hyperlipidemia, hypertension, diabetes or taking anticoagulant or n-3 PUFA supplementation;
- •having a taste aversion for fish, fish allergy or regular alcohol drinker;
- •body mass index > 40kg/m2;
- •pregnant or nursing women.
研究组 & 干预措施
capsules omega-3
Omega-3 supplementation (3g EPA+DHA/d)
干预措施: n-3 PUFA supplementation (Dietary Supplement)
结局指标
主要结局
Change in blood lipids (Total cholesterol, HDL-Cholesterol, Triglycerides)
时间窗: Before and after a 6-weeks supplementation
次要结局
- Change in anthropometric measures (waist and hip girth)(Before and after a 6-weeks supplementation)
- Change in plasma glycemia and insulin levels(Before and after a 6-weeks supplementation)
- Change in blood pressure(Before and after a 6-weeks supplementation)
- Change in gene expression levels(Before and after a 6-weeks supplementation)
研究者
Marie-Claude Vohl
Professeur
Laval University