NCT00052013已完成2 期
A Phase II Open-Label Study of Oral, Continuous, Once Daily PTK787/ZK 222584 in Patients With Von Hippel-Lindau Disease (VHL) and Hemangioblastoma (HB)
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Evaluate efficacy
研究概览
简要总结
The purpose of this study is to determine whether PTK787/ZK 222584 is effective in treating hemangioblastoma of the brain and/or retina in patients with von Hippel-Lindau disease. The study will also assess safety and tolerability of PTK787/ZK 222584, and changes in markers of angiogenesis (new blood vessel growth).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
PTK787/ZK 222584
Experimental
干预措施: PTK787/ZK 222584 (Drug)
结局指标
主要结局
Evaluate efficacy
次要结局
- Evaluate changes in dynamic contrast enhanced magnetic resonance imaging
- To explore the correlation of the pharmacokinetics
- To assess changes in surrogate markers of angiogenesis
研究者
研究点 (2)
Loading locations...
相似试验
已完成
2 期
Study of PTK787 in the Treatment of Patients With Non-Metastatic Androgen Independent Prostate CancerProstate CancerNCT00134355University of Michigan Rogel Cancer Center5
终止
2 期
PTK787 in Refractory or Relapsed Diffuse Large Cell LymphomaLymphoma, Large-Cell, DiffuseNCT00511043David Rizzieri, MD20
已完成
2 期
PTK787/ZK222584 in the Treatment of Metastatic Gastrointestinal Stromal Tumors Resistant to ImatinibSarcomaNCT00117299University of Helsinki45
已完成
3 期
Study of KHK7580 in Subjects With Secondary Hyperparathyroidism in AsiaSecondary HyperparathyroidismNCT03822507Kyowa Kirin Co., Ltd.404
已完成
2 期
PTK787 in Patients With Advanced Metastatic Pancreatic AdenocarcinomaNeoplasmNCT00226005Pancreatic Cancer Research Team67