Evaluation of Psychological Defense Mechanisms Used by Liver Transplant Patients on Their Somatic Psychological and Social Outcome. Research for Protective or Vulnerability Factors.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 81
- 试验地点
- 1
- 主要终点
- change in Bond Defense Style Questionnaire 88
研究概览
简要总结
Organ transplantation has a special place in the medical field. It symbolizes a medicine whose limits always seem to be repelled. Because transplantation is unusual, it places people in front of outstanding issues which he has to cope with his personality and history. Factors involved in the psychology of patient presenting with graft are past and present psychic functioning, object relations, experience of transplantation itself and quality of social environment.
Before or after graft defense mechanisms can be so intense that they can make the patient unable to overcome the graft. Yet as a pathological mechanism that denial was considered beneficial provided it is short.
The aim of this study is to evaluate on psychopathological influence of psychological defense mechanisms used by liver transplant patients on their somatic psychological and social outcome.
详细描述
The objective is to measure the influence of variations of psychological defense mechanisms.
The investigators want to measure the influence of personal history of patients, causal disease pre-existing, conditions of graft's realization, structure of patient's social environment (family or institutional); and wish to identify which of those elements can be protective or vulnerability factors with a view to allow adequate support (especially for patients who had multiple poor prognostic factors)
The investigators will study pre-transplant psychological defense mechanisms of the subjects using the Bond Defense Style Questionnaire and structure of personality using the SCID II personality scale. They will evaluate post-transplant patient outcomes on clinical and social developments with DSQ 88 and General Health Questionnaire (GHQ 28) to six months, twelve months and five years after transplantation. Meanwhile, they will address each time you visit the data on consumption, misuse and alcohol dependence using the AUDIT questionnaire (Alcohol Use Disorders Identification Test).
The hypothesis is that the defense mechanisms, their variations and personality of the patients are both vulnerability factors as protective factors in different phases of the graft. Identification should allow to optimize care and improve overall health. Results of this research could make it possible to determine the factors used in liaison psychiatry in the long term to ensure an adequate medical and psychiatric support to transplant patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients between 18 and 65 years old
- •liver disease requiring a liver transplantation
- •registered on the waiting transplant list in the University Hospital of Lille
排除标准
- •fulminant hepatitis
- •mental incapacity
结局指标
主要结局
change in Bond Defense Style Questionnaire 88
时间窗: baseline and 6 months and 1 year and 5 years
Change in psychological defense mechanisms measured by the Defense Style Questionnaire 88, prior and after liver transplantation
次要结局
- personality disorders evaluation by SCID II personality scale(baseline and 6 months and 1 year and 5 years)
- Minimal International Neuropsychiatric Interview MINI results(6 months and 1 year and 5 years)
- social evolution(baseline and 6 months and 1 year and 5 years)
- Alcohol Use Disorders Identification Test AUDIT score(baseline and 6 months and 1 year and 5 years)
- Change in mental health level by General Health Questionnaire GHQ 28(baseline and 6 months and 1 year and 5 years)