NCT00911677已完成不适用
Does Apolipoprotein E Genotype Predict Delirium and Postoperative Cognitive Dysfunction?
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Delirium as assessed by the Confusion Assessment Method
研究概览
简要总结
Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 60 or greater
- •Open repair of the abdominal aorta
排除标准
- •planned endovascular repair;
- •emergency surgery;
- •previous diagnosis of dementia, Parkinson's disease, or psychiatric illness;
- •active alcohol or substance abuse; and
- •physical inability to complete neuropsychometric testing.
结局指标
主要结局
Delirium as assessed by the Confusion Assessment Method
时间窗: 7 days postoperatively
次要结局
- POCD as assessed by a battery of 9 neuropsychometric tests(3 months postoperatively)
研究者
研究点 (1)
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