ACTRN12618001672246招募中未知
The effect of weekly rifapentine and isoniazid (3HP), compared to 4 months of daily rifampicin (4RIF) upon adherence with treatment for latent TB infection
Royal Prince Alfred Hospital, Sydney Local Health District0 个研究点目标入组 210 人开始时间: 2018年10月10日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 210
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 2 Years 至 o limit（—）
- 性别
- All
入选标准
- •1.Patients aged greater than or equal to 2 years old.
- •2.Eligible for treatment for LTBI, by either:
- •a.A TST of 10mm or greater, or
- •b.A positive Interferon Gamma Release Assay (IGRA), or
- •c.A negative TST in the presence of HIV infection in a contact of a person with confirmed tuberculosis infection.
- •3.Access to EITHER a mobile phone OR landline telephone (people who cannot use phone will be called instead of SMS).
排除标准
- •1.Presumptive tuberculosis in which TB has not been excluded
- •2.Confirmed tuberculosis.
- •3.Treatment for active tuberculosis.
- •4.History of isoniazid and/or rifampicin resistant tuberculosis.
- •5.Tuberculosis in the source case (i.e. ‘index’ case) known to be resistant to either isoniazid or rifampicin at the time of enrolment.
- •6.History of hypersensitivity to isoniazid, rifapentine, or rifamycins.
- •7.Medical conditions requiring the use of medication interacting with study medication
- •8.Weight of the participant < 10.0 kg
- •9.Currently pregnant, planning to become pregnant, or breastfeeding.
- •10.Consideration for solid organ transplantation.
- •11.Unable to give informed consent
- •12.AST over 3 times the upper limit of normal.
- •13.Known porphyria
研究者
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