CT based Radiomic analysis of radiation induced xerostomia in head and neck cancer radiotherapy patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Radiomic features such as shape based, first order, GLCM, GLRLM, GLSZM, NGDTM, GLDM
研究概览
简要总结
Xerostomia is common side effect of patients with head and neck cancer who will undergo Intensity modulated radiotherapy (IMRT) due to exposure of parotid glands to radiation. It affects the quality of life (QOL) of individual. Xerostomia is graded subjectively using Radiation Therapy Oncology Group (RTOG) scoring criteria. Radiomics is currently used in diagnosis, prognosis prediction. The objective of the study is to identify the significant CT based radiomic features useful for assessing xerostomia in head and neck cancer patients treated with IMRT. The patients with head and neck cancers who had undergone radiotherapy treatment and coming for follow up at least 6 months - 1 year will be evaluated and patients with xerostomia grading from 1-4 will be referred for CT Neck. The radiomic features of parotid gland will be extracted from pre and post radiotherapy images. Wilcoxon signed‑rank test will be performed to assess the significant changes in CT radiomic features of parotid glands in post radiotherapy relative to pre radiotherapy images
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with head and neck cancer treated with curative intent on follow-up of at least 6 months Clinically no evidence of recurrence disease No active treatment of cancer Non-metastatic disease at the time of follow-up.
排除标准
- •Patients with head and neck cancer treated with curative intent on follow-up without xerostomia CT images with motion artifacts.
结局指标
主要结局
Radiomic features such as shape based, first order, GLCM, GLRLM, GLSZM, NGDTM, GLDM
时间窗: Radiomic features extraction and analysis - once in 4 weeks
次要结局
未报告次要终点
研究者
Dr Saikiran P
Manipal College of Health Professions/Manipal Academy of Higher Education