NCT02120703已完成3 期
Gabapentin vs. Pregabalin for Post Operative Pain in Lumbar Microdiscectomy: a Randomized Controlled Trial.
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- Pain
研究概览
简要总结
Pregabalin is claimed to have superior analgesic effect at lower doses and better pharmacological profile as compared to gabapentin esp. in perioperative pain control after major surgeries like intervertebral disc surgery.
The investigators found that pregabalin is equivalent to gabapentin for relief of post-operative pain at a lower dose in patients undergoing intervertebral disc surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •30-60 years age
- •Any gender
- •elective micro discectomy for intervertebral disc prolapse
排除标准
- •micro discectomy at two or more vertebral levels,
- •Instrumentation i.e. pedicle screw fixation, hooks etc.,
- •history of steroids or alcohol use,
- •Multiple co-morbids i.e. renal failure, chronic liver disease,
- •use of anticonvulsant drugs,
- •Spinal deformity,
- •Obesity (BMI >30), 8) inability to understand and respond VAS and
- •patients with known allergy to GABA analogues.
研究组 & 干预措施
Pregabalin
Active Comparator
干预措施: Pregabalin (Drug)
gabapentin
Active Comparator
干预措施: Gabapentin (Drug)
结局指标
主要结局
Pain
时间窗: 7 days
Pain measurement using Visual Analogue Score at 24 hours and 7th day of surgery
次要结局
未报告次要终点
研究者
研究点 (1)
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