Randomized trial of citalopram plus vitamins B12, B6 and folate versus citalopram plus placebo for the treatment of depressive episodes amongst adults aged 50 years or over

niversity of Western Australia0 个研究点目标入组 155 人开始时间: 2009年5月13日最近更新: 2020年1月13日

试验速览

暂无简介。

•age 50 years or over, of either sex - meet Diagnostic and Statistical Manual of Mental Disorders (4th edition) criteria for the diagnosis of major depressive episode within the context of a depressive disorder - Montgomery-Asberg Depression Rating Scale (MADRS) score of 20 or more - fluent in written and spoken English.

•- evidence of concurrent alcohol or substance abuse or dependency (Alcohol Use Disorders Identification Test – AUDIT = 7),
•- clinical evidence of Parkinson’s disease (including treatment),
•- prior clinical history of strokes,
•- evidence of clinically significant cognitive impairment (i.e., Mini-Mental State Examination – MMSE score < 24),
•- evidence of medical morbidity (such as cancer) that may compromise 12-month survival or availability for study assessments,
•- currently receiving antidepressant treatment (antidepressant medication or electroconvulsive therapy),
•- use of B-vitamins daily for more than 3 months, or receive regular B12 injections
•- prior allergic reaction to citalopram or escitalopram,
•- use of a monoamine oxidase inhibitor during the preceding 2 weeks,
•- no active general practitioner,
•- suicide plans,
•- no written informed consent.

发起方

niversity of Western Australia