NCT02114710已完成3 期
Study of Little Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
Nanjing PLA General Hospital0 个研究点目标入组 240 人开始时间: 2009年5月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 240
- 主要终点
- death
研究概览
简要总结
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock. And discuss the probable mechanism by which little doses of hydrocortisone influence coagulation system in sepsis.
详细描述
Patients were randomized to receive either low-dose hydrocortisone or matching placebo.Severity of coagulopathy was estimated using ISTH DIC score. We determined the complications and mortality in two groups, and analyzed the relationship between hydrocortisone and coagulopathy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 78 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients(age≧18y)
- •Admitted for septic shock were considered eligible if they had no life-threatening systemic disease (ASA groups 1~3)
排除标准
- •Lactation
- •Mental disorders
- •Disseminated cancer
- •Secondary cancers
- •Inflammatory bowel disease, or diseases hindering epidural analgesia
研究组 & 干预措施
Hydrocortisone
Experimental
little doses of hydrocortisone
干预措施: Hydrocortisone (Drug)
结局指标
主要结局
death
时间窗: 30 days after inclusion
次要结局
- clinical perioperative complications(30 days after inclusion)
- clinical complications(30 days after inclusion)
研究者
Gao Tao
Nanjing PLA General Hospital
Nanjing PLA General Hospital
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