Effect of Aerobic Interval vs. Continuous Exercise Training on Cardiovascular Function in Aging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in vascular endothelial function
研究概览
简要总结
Study objectives:
- To compare cardiovascular function in older compared to young healthy adults.
- To compare the effect of 8 weeks of aerobic interval training vs. continuous moderate exercise on cardiovascular function in healthy older adults.
Hypotheses:
- Compared to young adults, older adults will have lower cardiovascular function.
- Compared to continuous moderate intensity exercise training, interval training will be more effective in improving cardiovascular function in older adults.
详细描述
Cardiovascular function will be measured at baseline in older healthy adults and young healthy controls. Older adults will be randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week exercise intervention, baseline measures will be repeated in the older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for older adults:
- •Healthy men and women 55 to 79 years of age
- •Sedentary or minimally physically active for at least the prior 1 year.
- •Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
- •Premenopausal women will be eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
- •Able to give consent.
- •Inclusion Criteria for young adults:
- •Healthy men and women 18 to 35 years of age
- •Sedentary or minimally physically active for at least the prior 1 year.
- •Women will be premenopausal, eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
- •Able to give consent.
排除标准
- •history of diabetes
- •history of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia)
- •hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)
- •history of renal impairment
- •history of gout or hyperuricemia
- •history of hepatic disease or infection with hepatitis B, C
- •history of seizures, or other relevant on-going or recurrent illness
- •recent (within 3 months) or recurrent hospitalizations
- •use of tobacco products
- •>5 % weight change in the prior 6 months.
- •current intake of medications that may affect study results
- •participation in regular aerobic exercise training (>30 minutes,
- •3 times/wk in the past year).
- •premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
- •pregnancy (positive urine pregnancy test) or lactation
研究组 & 干预措施
High intensity aerobic interval training
Older adults will complete 8 weeks of high intensity aerobic interval exercise training.
干预措施: High intensity aerobic interval training (Other)
Continuous moderate intensity exercise
Older adults will complete 8 weeks of continuous moderate intensity exercise training.
干预措施: Continuous moderate intensity exercise (Other)
Non-exercise control group
Older adults assigned to the non-exercise control group will maintain their normal lifestyle for 8 weeks.
Young Healthy controls
Young healthy subjects will be assigned to the healthy control group and will undergo baseline measures only.
结局指标
主要结局
Change in vascular endothelial function
时间窗: At baseline and after 8 weeks of exercise training
Brachial flow-mediated dilation using ultrasonography
次要结局
- Change in cardiac function(At baseline and after 8 weeks of exercise training)
- Change in arterial stiffness(At baseline and after 8 weeks of exercise training)
- Change in factors related with endothelial function(At baseline and after 8 weeks of exercise training)
- Change in maximal oxygen consumption(At baseline and after 8 weeks of exercise training)