Investigating the Efficacy of Probiotic Supplementation in the Management of Allergic Rhinitis: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- To asses Effectiveness of reducing symptoms and immunology marker levels .i.e. AEC count and Ige and diagnostic nasal endoscopy using probiotics as an adjunct with standard treatment for patients having Allergic Rhinitis.
研究概览
简要总结
Allergic rhinitis is a common inflammatory condition of the nasal mucosa, characterized by symptoms such as nasal congestion, rhinorrhoea, sneezing, and nasal itching, often triggered by allergens. It affects a noteworthy portion of the population worldwide, leading to impaired quality of life, productivity losses, and substantial healthcare costs. The current standard treatments for allergic rhinitis include antihistamines, intranasal corticosteroids, and allergen immunotherapy.
Recent research has increasingly focused on the role of the gut microbiota in modulating immune responses and inflammatory conditions, including allergic diseases.
Probiotics, are defined as live microorganisms that offer health benefits when administered in adequate amounts.
Several studies have suggested that specific probiotic strains can promote immune tolerance and reduce allergic responses.
Despite the promising evidence we have failed to document the evidence of the use of probiotics in individuals with allergic rhinitis in the area specific to Pondicherry and Cuddalore of Tamil Nadu.
This study aims to contribute to the growing body of evidence by conducting a randomized controlled trial to investigate the impact of probiotics on allergic rhinitis symptoms and immune markers.
Aim
- To asses Effectiveness of reducing symptoms and immunology marker levels .i.e. AEC count and Ige using probiotics as an adjunct with standard treatment for patients having Allergic Rhinitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 18 upto 50 years attending ENT OPD in AVMC presenting with symptoms of allergic rhinitis with blood investigations supporting the diagnosis of allergic rhinitis.
排除标准
- •Patients with a history of severe allergic reactions or other significant comorbidities.
- •Patients currently using probiotics or undergoing immunomodulatory therapy.
- •Pregnant or lactating women.
- •Patients previously diagnosed with GERD.
结局指标
主要结局
To asses Effectiveness of reducing symptoms and immunology marker levels .i.e. AEC count and Ige and diagnostic nasal endoscopy using probiotics as an adjunct with standard treatment for patients having Allergic Rhinitis.
时间窗: To asses Effectiveness of reducing symptoms and immunology marker levels at 2 weeks , 4 weeks ,6 weeks
次要结局
- To establish the association of Laryngeal reflux/Gastro- oesophageal reflux with allergic rhinitis.(at 2 weeks , 4 weeks ,6 weeks)
研究者
Dr Bhairavi Sharma
Aarupadai Veedu Medical College and Hospital