Circadian Mechanisms of Cardiovascular Risk in Obesity
试验速览
- 阶段
- 早期 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- Blood Pressure
研究概览
简要总结
A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk, with an additional focus on obesity. Specifically, in a valid circadian protocol, the investigators aim to study resting cardiovascular risk markers and the reactivity of circadian rhythms in these risk markers to standardized stressors. It is intended to compare results in lean and obese individuals to determine if there are specific risks across the circadian cycle specific to obesity. Furthermore, using an exploratory approach, the investigators propose to explore impairment in pre/post synaptic function in the cardiac left ventricle.
详细描述
Overall, these studies will help us answer whether the circadian system predispose individuals to increased CV disease risk - particularly around the vulnerable morning period, and whether these risks differ with obesity. The results will serve as a foundation for clinical trials of appropriately timed dosing of medications targeting aspects of the CV system that increase effectiveness while decreasing side effects, and may have particular relevance to management of CV risk in people with obesity.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 25-65
- •Lean and overweight (BMI 18.5-40kg/m2)
- •Habitually sedentary
排除标准
- •History of smoking/tobacco use
- •Moderate to severe obstructive sleep apnea.
- •Prior shift work within 6 months prior to the study.
- •Prescription medications
- •Drugs of abuse
- •Acute, chronic, or debilitating medical condition (including diabetes, hypertension, and metabolic syndrome)
结局指标
主要结局
Blood Pressure
时间窗: 5 Days
Beat-by-beat and ambulatory blood pressure measurements.
次要结局
- Epinephrine(5 days)
- Cortisol(5 days)
- Coronary Microvascular Blood Flux(3 days)
- Flow Mediated Dilation (FMD)(5 days)
- Heart Rate(5 Days)
- Norepinephrine(5 days)
- Epinephrine(5 days)
- Cortisol(5 days)
- Flow Mediated Dilation (FMD)(5 days)
- Coronary Microvascular Blood Flux(3 days)
研究者
Steven A. Shea
Director
Oregon Health and Science University