A pilot investigation of the effect of cathodal transcranial direct current stimulation (ctDCS) plus standard upper limb rehabilitation to augment motor recovery post acute stroke.

Sir Charles Gairdner Hospital0 个研究点目标入组 37 人开始时间: 2013年1月29日最近更新: 2020年1月13日

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•All ischaemic strokes admitted to Sir Charles Gairdner Hospital under a consultant neurologist will be screened. A total of 37- 40 participants will be recruited for this study.
•All subjects must meet the following inclusion criteria:
•1. First ever ischaemic stroke (cortical or subcortical involving the territory of the middle cerebral artery (MCA) based on imaging findings.
•2. Stroke onset less than 1 week prior to study enrolment.
•3. Moderate to severe hemiparesis based on the Fugl Meyer Upper Extremity assessment (35-52 moderate and less than 35 severe upper limb deficit).
•4. Detectable motor evoked potentials (MEPs) in the affected hand muscles via TMS assessment.
•5. Stable blood pressure parameters within limits approved by treating neurologist.
•6. Age between 18 to 80 years old.
•7. MMSE greater than 24

•1. Pre-existing upper limb impairment causing functional limitation
•2. Hemiplegic shoulder pain
•3. Metallic foreign body implant (pacemaker or artificial cochlea)
•4. History of seizure or another unstable medical condition
•5. Pregnancy
•6. Severe language disturbance (Frenchay Aphasia Screening Test will be used to identify participants with communication difficulties; a more detailed evaluation will be performed by a speech pathologist to determine severity of language impairment).
•7. English as a second language
•8. Severe Neglect (score of < 44 out of 54 points on the Star Cancellation test)
•9. History of depression, alcohol or drug abuse
•10. Coexistent neurological or psychiatric disease
•11. Current treatment with antidepressants, antipsychotics or benzodiazepines
•12. Current treatment with Na+ or Ca 2+ Channel blockers or N-methyl-D-aspartate (NMDA) receptor antagonists.

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