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临床试验/NCT02754089
NCT02754089已完成不适用

The Effects of Rhus Coriaria L. (Rhus or Somagh) on Body Weight

Shiraz University of Medical Sciences1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2016年5月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
已完成
入组人数
50
试验地点
1
主要终点
Body Mass Index

研究概览

简要总结

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as "Somagh" on body weight.

详细描述

Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Body mass index (BMI) >= 25 kg/m2

排除标准

  • Diabetes mellitus
  • Hypo. or hyperthyroidism
  • Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure
  • Use of drugs: Weight lowering agents, glucocorticoids, Oral contraceptive pills.
  • Pregnancy
  • History of allergic reaction to Somagh

研究组 & 干预措施

Rhus

Experimental

500 mg twice daily after meal for 6 weeks

干预措施: Rhus Coriaria L.(Rhus) (Drug)

Placebo

Placebo Comparator

500 mg twice daily after meal for 6 weeks

干预措施: Placebo (Drug)

结局指标

主要结局

Body Mass Index

时间窗: 6 weeks

次要结局

  • Waist Circumference (cm)(6 weeks)
  • Hip Circumference (cm)(6 weeks)
  • Leptin (ng/ml)(6 weeks)
  • Insulin (mU/l)(6 weeks)
  • Fasting Blood Glucose (mg/dl)(6 weeks)
  • Number of patients with adverse event(6 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mesbah Shams, MD

Associate professor of Internal Medicine & Endocrinology

Shiraz University of Medical Sciences

研究点 (1)

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