Rapid Cool: Heat Stroke Treatment
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 20
- 主要终点
- Cooling Rate
研究概览
简要总结
Hot climates such as in Phoenix, AZ commonly have individuals experiencing heat stroke, a life-threatening medical emergency. The dangerously high body temperature can result in death if not treated immediately with rapid body cooling. Rapid core temperature reduction within 30 min of diagnosis results in 100% survival and positive outcomes. While this is easily achieved with whole-body cold water immersion, this modality is not feasible in an ambulance.
The Phoenix emergency medical services protocol consists of lying the patient on a large volume of ice. While this is somewhat effective, this cooling strategy results in a sub-optimal cooling rate, difficulty obtaining this large volume of ice, and a very wet ambulance as the ice melts. Recently, a company created a cooling strategy that utilizes a small amount of ice and a small amount of recirculated water to keep the patient cool. The purpose of this study is to determine the core temperature cooling rate of this cooling strategy and compare it to the cooling rate of the currently used Phoenix protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult participant (18 - 39 years old)
- •Body mass index (BMI) 18 - 30 kg/m2
- •At least moderate intensity aerobic exercise ≥60 min per week
- •Participant is able and willing to follow study procedures
排除标准
- •History of cardiovascular, neurological, metabolic, pulmonary, renal, gastrointestinal, or autoimmune disease
- •Taking prescription medication (with exception of psychiatric medication)
- •If taking a psychiatric medication, the dosage has changed within the month prior to first study visit
- •Cannot abstain from taking over-the-counter medications or supplements for 24 hours before study visits (with exception of vitamins)
- •Resting systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥90 mmHg
- •Resting heart rate of ≥100 beats per minute
- •Regular smoker of cigarettes or has regularly smoked in the past year
- •Musculoskeletal injury/condition that negatively impacts the protocol
- •History of heat illness that resulted in a visit to a medical center in the past 2 years
- •Has donated blood or plasma in the past 3 months
- •Has taken antibiotics or corticosteroids within 4 weeks of enrollment
- •Has a medical implant device such as a pacemaker, patient monitoring system, or metallic implant
- •Has a full or partially amputated limb
- •Pregnant or breastfeeding
- •Study physician or PI discretion based on any other medical condition or medication
结局指标
主要结局
Cooling Rate
时间窗: 30 minutes post-exercise
Internal body temperature reduction throughout cooling
次要结局
未报告次要终点
研究者
Riana Pryor
Principal Investigator
State University of New York at Buffalo