NCT00223054已完成不适用
Polymorphism of the Cytochrome P450-system and the MDR-system in Renal Transplants Receiving the Immunosuppressive Drugs Tacrolimus, Sirolimus, Everolimus or Cyclosporine A
University Hospital Schleswig-Holstein1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2005年3月最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
研究概览
简要总结
In this study the researchers want to investigate genetic polymorphisms of cytochrome 450 enzymes and the multiple drug resistance (MDR) gene in renal transplant patients to look for differences in dosing of immunosuppressive drugs (tacrolimus, sirolimus, everolimus, cyclosporine A).
All patients who receive one of these drugs can be included and drug blood trough levels, dosing and genetics are compared.
详细描述
Primary endpoint is the
- serum creatinine in patients with and without polymorphysms
- rate of rejections in patients with and without polymorphysms
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Renal transplant patients receiving one or more of the following drugs:
- •tacrolimus
- •sirolimus
- •everolimus
- •cyclosporin A
- •fluvastatin
- •Informed consent given by the patient
排除标准
- 未提供
研究者
研究点 (1)
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