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临床试验/NCT07318987
NCT07318987招募中不适用

EFFECT OF SAPHENOUS NERVE RELEASE ON PAIN,BALANCE AND FUNCTION IN PATIENTS WITH PATELLOFEMORAL PAIN SYNDROME

Cairo University1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2025年10月10日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
36
试验地点
1
主要终点
knee pain

研究概览

简要总结

Patellofemoral Pain Syndrome (PFPS) is a frequent cause of anterior knee pain in young, physically active individuals, especially females, and is commonly managed with quadriceps and hip-focused exercises. However, the role of neural factors has been largely overlooked. The saphenous nerve, which supplies sensation to the anteromedial knee, may become irritated or entrapped and contribute to pain and neuromuscular dysfunction in PFPS. This study suggests that manual therapy targeting the saphenous nerve could improve pain, function, and balance, providing a more holistic approach to PFPS rehabilitation.

详细描述

Patellofemoral Pain Syndrome (PFPS) is a common cause of anterior knee pain, particularly affecting adolescents and young adults, with a higher prevalence among females. It accounts for a significant proportion of knee complaints seen in sports medicine and is especially common in physically active individuals. Traditional rehabilitation for PFPS has mainly focused on quadriceps strengthening and knee mechanics, with more recent attention given to hip-focused exercises.

However, the neural contribution to PFPS, particularly involving the saphenous nerve and its infrapatellar branch, has been relatively under-explored. The saphenous nerve is a purely sensory branch of the femoral nerve that supplies the anteromedial knee and lower leg and plays an important role in proprioception. Anatomical variations and its course near the sartorius muscle may predispose it to irritation or entrapment, potentially contributing to chronic anteromedial knee pain.

This study proposes that irritation or mechanosensitivity of the saphenous nerve may be a contributing factor in PFPS, leading to pain and impaired neuromuscular control. By incorporating manual therapy targeting the saphenous nerve, the research aims to fill a gap in current PFPS management. Addressing neural factors may enhance pain reduction, functional performance, and balance, offering a more comprehensive and holistic physiotherapy approach for individuals with PFPS. (summarize in short)

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • 1 - Age from 18 to 35 and BMI 18 to 25 kg/m
  • Both gender (male and female)
  • Patients who had anterior knee pain for at least six weeks
  • Patients with positive saphenous neurodynamic test (SAPHNT)

排除标准

  • Knee replacement
  • An intraarticular injection within the past 3 months
  • Previous operative treatment or arthroscopy, other secondary knee-related problems (bursitis, tendinopathy, osteochondritis, neuromas, intraarticular pathology (such as osteoarthritis), tumor, and rheumatologic diseases
  • Diabetic neuropathic pain or fibromyalgia

结局指标

主要结局

knee pain

时间窗: up to 6 weeks

Visual analogue scale to measure pain intensity

Balance

时间窗: up to 6 weeks

Using the Biodex Stability System (Biodex balance system), static balance was measured

Function

时间窗: up to 6 weeks

Kujala Anterior Knee Pain Scale (AKPS) for knee pain and function, The Kujala score is composed of 13 multiple choice questions: the presence of a limp, the need for support, the ability to walk, the ability to climb stairs, the ability to squat, the ability to run, the ability to jump, prolonged sitting with knees in the flexed position, the presence of knee pain, the presence of knee swelling, the presence of abnormal painful patellar movement, atrophy of the thigh muscles, and deficiency of knee flexion.

次要结局

  • Q angle(up to 6 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Markos Boshra Agaiby Amin

Teaching assistant

Cairo University

研究点 (1)

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