Sleep Quality in CHIMES (MF101)
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 180
- 试验地点
- 3
- 主要终点
- Actigraph watch (SleepWatch-O, Ambulatory Monitoring, Inc., Ardsley, NY)
研究概览
简要总结
Menopausal women often complain of difficulty sleeping and the transition from pre- to postmenopausal status is associated with an incresase in self-reported sleep disturbance. Hot flashes have been associated with self-reported measures of sleep disturbance and changes in sleep pattern as measured by plysomnography, including an increase in stage 4 and a latency or shortened time in rapid-eye movement sleep. Although there are some data on the effect of hormone replacement therapy on self-reported sleep measures in symptomatic postmenopausal women, there are no data on the effect of herbal extracts on subjective or objective measures of sleep quality in this population group. Actigraphy, the use of a device to record movement generally placed on the wrist, has been used over 20 years to provide objective data concerning sleep/wake patterns. The advantage of actigraphy over traditional polysomnography is that actigraphy can conveniently record continuously for 24-hours a day for longer periods of time.
详细描述
Specific Aims:
- To determine the effect of MF101 (a combination of Chinese herbs) compared to placebo on change in sleep quality utilizing baseline and follow-up actigraphy obtained from a subset of approximately 90 women enrolled in the randomized, double-blind, placebo-controlled Chinese Herbs for Menopausal Symptoms (CHIMES) trial.
- TO identify the correlates of sleep quality as assessed by actigraphy in women with frequent hot flashes. We will evaluate demographic, lifestyle, anthropometric, medical and gynecologic history and hormonal factors that may relate to the actigraphic measures of sleep quality, including self-reported measures of sleep.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women between the ages of 40 to
- •Currently receiving medical care from a health care provider.
- •Self-report 5 hot flashes per day or 35 hot flashes per week.
- •Postmenopausal as defined by 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum FSH levels > 30mlU/ml or 6 weeks post-surgical bilateral oophorectomy with or without hysterectomy or hysterectomy with FSH levels > 30 mlU/ml.
- •Agree not to start new herbal or dietary supplements and not to change the dose of any currently used herbal or dietary supplements for the duration of the trial.
- •Successful completion of a Hot Flash Diary, a Daily Study Medication Diary and a Bleeding Diary, tolerates placebo, and 80% compliant at run-in.
- •Must have had a mammogram within the last 9 months.
- •Have access to a phone.
- •Provide informed consent.
排除标准
- •Inability to sign an informed consent or fill out questionnaires.
- •History of breast, uterine or ovarian cancer or melanoma.
- •Abnormal mammogram or breast examination within the last 9 months suggestive of cancer.
- •Abnormal Pap smear or pelvic examination within the last 9 months suggestive of cancer.
- •Double-wall endometrial thickness that exceeds 5 mm measured on transvaginal ultrasound.
- •Unexplained abnormal uterine bleeding within six months of enrollment.
- •Pregnancy or lactating.
- •Clinical evidence of active ischemic cardiovascular disease or a history of cardiovascular disease.
- •History of deep vein thrombosis or pulmonary embolism requiring anticoagulation.
- •Active liver or gallbladder disease.
- •Use of medications, herbal or dietary supplements known to possibly be effective for the treatment of hot flashes within three months of enrollment for oral or transdermal drugs, or within 6 months of enrollment for implanted or injected drugs.
- •Use of raloxifene or tamoxifen within three months of enrollment.
- •Use of another investigational agent within 3 months of enrollment.
- •History of multiple or severe food or medicine allergies.
- •Any medical or psychiatric condition that, in the investigator's opinion, would preclude the participant from adhering to the protocol or completing the trial, including severe illness, plans to move, substance abuse, significant problems, or dementia.
结局指标
主要结局
Actigraph watch (SleepWatch-O, Ambulatory Monitoring, Inc., Ardsley, NY)
次要结局
未报告次要终点