Predicting Treatment Resistance in Schizophrenia - TREVOS

Academisch Medisch Centrum0 个研究点目标入组 120 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•- Antipsychotic use longer than one year
•- Dependence on other substances of abuse than nicotine or cannabis
•- Use of amphetamine, cocaine or medication for ADHD (attention deficit hyperactivity disorder), since these drugs influence the dopamine system
•- Neurological disorder (e.g. epilepsy) or evidence of brain damage
•- Inability to provide informed consent;In addition to the exclusion criteria mentioned above, healthy control subjects are not allowed to have any kind of psychiatric disorder;Exclusion criteria directly related to MRI scanning:
•- Contra-indications for MRI (including pacemaker, ferromagnetic implants, claustrophobia)
•- Pregnancy;Exclusion criteria directly related to PET/CT scanning (for subgroup of 40 patients):
•- Participation in a scientific examination where radiation was used, in the last year.
•- Positive urine drug screen on the day of the PET/CT scan. Participants will be tested on cannabis, amphetamine, XTC, cocaine and opiates. Only recent cannabis use will be accepted.
•- In women: positive pregnancy test on the day of the PET/CT scan and lactation.

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