NCT03159741已完成不适用
Investigation of GLP-2 Mechanism of Action (GA-8)
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- C-terminal telopeptide (CTX)
研究概览
简要总结
Glucagon-like peptide-2 (GLP-2) is a naturally occuring hormone secreted to the circulation in response to food ingestion. Previous studies have shown that GLP-2 and incretins inhibit the bone resorption. However, the mechanism is unknown. In the present study we will investigate the mechanism of action using a receptor specific inhibitor.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy, 20 to 40 years old, caucasian, BMI 18,5 to 24,9 kg/m2
排除标准
- •Chronic disease, smoking, medication, weight change more than 3 kg whitin the last 3 months, overweight surgery, intestinal surgery, Hgb<8,0 mmol/L, decreased renal function.
研究组 & 干预措施
Placebo + GIP
Active Comparator
干预措施: Placebo + GIP (Other)
Placebo + Saline
Placebo Comparator
干预措施: Placebo + Saline (Other)
Inhibitor + GLP-2
Experimental
干预措施: Inhibitor + GLP-2 (Other)
Placebo + GLP-2
Experimental
干预措施: Placebo + GLP-2 (Other)
结局指标
主要结局
C-terminal telopeptide (CTX)
时间窗: -30 to 240 min.
Marker of bone resorption
次要结局
- Glucose(-30 to 240 min.)
- Osteocalcin (OC)(-30 to 240 min.)
- Parathyroid hormone (PTH)(-30 to 240 min.)
- Osteoprotegerin (OPG)(-30 to 240 min.)
- Glucose-dependent insulinotropic polypeptide (GIP)(-30 to 240 min.)
- Glukagon-like peptide-1 (GLP-1) and glukagon-like peptide-2 (GLP-2)(-30 to 240 min.)
- N-terminal propeptide of type 1 procollagen (P1NP)(-30 to 240 min.)
- Glukagon and pancreatic polypeptide (PP)(-30 to 240 min.)
- Insulin/c-pep.(-30 to 240 min.)
研究者
Kirsa Skov-Jeppesen
Investigator
University of Copenhagen
研究点 (1)
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