Filamin A Expression in HCC Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 115
- 主要终点
- Rate of expression of Filamin A (FLNA) in HCC specimens from patients resected for HCC.
研究概览
简要总结
The risk of recurrence after hepatectomy for hepatocellular carcinoma (HCC) is very high. Having a predictive marker of early recurrence (ER) would be desirable to personalize the follow-up and possibly develop new targeted therapy. The aim of this study was to test the expression of Filamin A (FLNA) in a cohort of patients operated for HCC.
详细描述
A consecutive cohort of resected HCC patients will be analyzed. Several different prognostic factors, including FLNA expression, will be tested against the risk of ER. FLNA expression will be analyzed with immunohistochemistry in the intra-tumoral and extra-tumoral tissue compartments using a dedicated tissue microarray.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The inclusion criteria were represented by the histological positivity for HCC with complete clinical, surgical, pathological, and follow-up data.
排除标准
- •Patients preoperatively treated with chemotherapy or trans-arterial therapy were excluded.
- •Similarly, patients operated for recurrent HCC or with non-radical surgery or with missing data were excluded.
结局指标
主要结局
Rate of expression of Filamin A (FLNA) in HCC specimens from patients resected for HCC.
时间窗: 2 years after surgery as a minimum follow-up
The rate of expression of FLNA in HCC specimens will be measured using standard immunohistochemistry methodology on surgical specimens. Such expression rate will be correlated to several different clinical and pathological parameters.
次要结局
未报告次要终点
研究者
Prof. Guido Torzilli
Professor of Surgery, Director Department of Hepatobiliary and General Surgery
University of Milan