Predictive Nature of Total Cholesterol Threshold: Possible Link to Suicidal Behavior
试验速览
- 阶段
- 不适用
- 入组人数
- 555
- 试验地点
- 2
- 主要终点
- frequency of suicide attempts
研究概览
简要总结
Suicidal behavior (SB) is a public health problem. The clinical model currently admitted to the understanding of SB is a stress vulnerability model, but so far, all scientific works has no clinical application. The management of psychiatric patients, including depressed subjects, faces the inability to detect those with a high risk of SB. Many studies have shown a link between low cholesterol and SB. A study has recently proposed a total cholesterol threshold below which the risk of suicide could be increased. However, a prospective study is needed to assess the predictive nature of such an indicator.
详细描述
Investigators propose to assess, within a cohort of patients, the predictive value of a total cholesterol threshold in the occurrence of SB.
555 inpatients suffering from a current Major depressive disorder (MDD), hospitalized in the Department of Emergency Psychiatry and Post Acute Care will be recruited.
Each patient will attend a total of 5 visits during a follow-up period of 18 months (visits at 1, 3, 6, 12, and 18 months)
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
frequency of suicide attempts
时间窗: at 18 month
frequency of suicide attempts during the 18months follow-up, according to the total cholesterol threshold at baseline. The biological sampling is carried out after 12 hours of fasting.
次要结局
- depression (Quick Inventory of Depressive Symptomatology)(at 18 month)
- relation between inflammatory markers and the occurrence of SB(at 18 month)
- relation between thyroid function and the occurrence of SB(at 18 month)
- scores to Iowa Gambling Task Time frame: 18 months(at 18 month)
- depression level (Inventory of Depressive Symptomatology)(at 18 month)
- National Adult Reading Test score ( NART)(at 18 month)
- verbal fluency(at 18 month)
- number of past SB(at 18 month)
- scores to verbal fluency(at 18 month)
- relation between pharmacological assays and the occurrence of SB(at 18 month)
- relation between the characteristic of the mood depressive disorder (unipolar or bipolar depression) and the predictive or vulnerability factors of SB(at 18 month)
- relation between thyroid function and the response to antidepressant treatment(at 18 month)
- depression level (Quick Inventory of Depressive Symptomatology)(at 18 month)
- the characteristic of past SB(at 18 month)
- National Adult Reading Test score(at 18 month)
- scores to Iowa Gambling Task(at 18 month)
- relation between lipid profile and the response to antidepressant treatment(at 18 month)
- lethality of past SB(at 18 month)
- Depression (Inventory of Depressive Symptomatology)(at 18 month)
- depression level (Beck depression Inventory)(at 18 month)
- relation between lipid profile and the occurrence of SB(at 18 month)
- relation between inflammatory markers and the response to antidepressant treatment(at 18 month)
- Depression (Beck Depression Inventory)(at 18 month)
- relation between pharmacological assays and the response to antidepressant treatment(at 18 month)
- scores to California Verbal Learning Test(at 18 month)
- score to the brixton test(at 18 month)
- scores to Reversal Learning Task(at 18 month)
- scores to the Attentional Stroop test(at 18 month)
- moral pain(at 18 month)
- physical pain(at 18 month)
- suicidal ideation(at 18 month)
- history of childhood abuse(at 18 month)