Transcranial Magnetic Stimulation Used to Treat Auditory Hallucinations in Schizophrenia
试验速览
- 阶段
- 4 期
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Hoffman Auditory Hallucination Scale
研究概览
简要总结
Schizophrenia is a chronic, severe, and disabling brain disease. Auditory hallucinations are the most frequent symptoms with an incident of 50% to 70% in patients.
Transcranial Magnetic Stimulation (TMS) can significantly reduce symptoms of schizophrenia. TMS is capable of inducing changes in the electrical activities of the brain in humans.
The purpose of this trial is to study the use of TMS to decrease auditory hallucinations in schizophrenia.
详细描述
We hypothesize that: True treatment with rTMS will have significant decrease in auditory hallucinations versus sham treatment over the temporoparietal cortex.
FMRI will highlight areas of activation with auditory hallucinations distinct from the area identified by Hoffman's scalp based method.
Cortical inhibition as measured by paired pulse TMS will be increased after true TMS but not sham TMS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Schizophrenia
- •Auditory hallucinations occuring more than 5 times per day
- •Adequate (6 weeks) trial of antipsychotic medication
- •Including at least 1 atypical antipsychotic medication
- •Medication stable for 4 weeks prior to commencement of the study
- •Competent to consent
排除标准
- •history of seizure disorder in patient or first degree relative
- •recent head injury
- •Acute suicidality
- •Alcohol or substance abuse
- •Implanted pacemaker or metal in head or neck
- •Pregnancy
结局指标
主要结局
Hoffman Auditory Hallucination Scale
时间窗: weekly
A series of 7 questions to identify the intensity and severity of the hallucinations
次要结局
- Positive and Negative Syndrome Scale for Schizophrenia (PANSS)(2 weeks)