G- Forces On Retrieved ChildrEn Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Correlation between physiological parameters and G-forces during transport episode
研究概览
简要总结
G-Forces On Retrieved ChildrEn (Pilot) Study is a feasibility study looking at the effect of G-Forces in vivo during episodes of paediatric critical care transport. The study aims to (i) understand the relationship between the physics of transport on physiological parameters and (ii) assess whether syringe driver delivery (previously demonstrated to be affected by G-forces in vitro), is responsible for physiological variations in transported paediatric patients requiring vasoactive/inotropic infusions.
详细描述
Throughout the UK, paediatric transport services are responsible for the stabilisation and transport of critically unwell children. This involves moving children from district general hospitals to receive specialist care in tertiary centres and moving children between tertiary and quaternary centres in order to provide the appropriate level of specialist care.
Critically unwell children often require infusions of essential, life-saving medications during episodes of transport. Disruption of these infusions can be destabilising and even life-threatening. Examples of essential infusions include the use of prostin in duct-dependent congenital heart disease, vasoactive/inotropic medications in shock and sedation and muscle relaxants to ensure comfortable, safe transfer.
Critically unwell patients often require support in the form of inotropes/vasopressors to support cardiac contractility and alter vascular tone and are commonly used in the treatment of shock. Physiological response to vasoactive/inotropic drugs is rapid and measurable in terms of cardiovascular status through observing changes in heart rate, blood pressure and oxygenation of peripheral tissues (pulse oximetry). As such these medications offer the potential to observe whether syringe driver delivery variations as mediated through the effect of g-forces exert measurable physiological instability in transported patients.
G-Forces Pilot is a prospective, observational, case-control, feasibility study investigating the effect of G-forces as measured by an accelerometer against physiological parameters of heart rate, invasive blood pressure measurement and oxygen saturations in vivo during episodes of transport. The study aims to understand the relationship between the physics of transport on physiological parameters and to assess whether syringe driver delivery (previously demonstrated to be affected by G-forces in-vitro), is responsible for physiological variations in transported patients requiring vasoactive/inotropic infusions.
The investigators propose to examine this relationship by obtaining and analysing data on physiological parameters in patients during episodes of transport to assess:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(i) Any child, 36 weeks corrected gestation to 18 years, accepted for transport by the COMET retrieval service who has an arterial line with active arterial blood pressure monitoring at departure from the referring hospital. The decision for the need for an arterial line is determined purely on a clinical basis by the referring, transporting or accepting clinical team.
排除标准
- •(i) Children outside the specified age range.
- •(ii) Children who do not have invasive arterial blood pressure monitoring during a transport episode.
- •(iii) Any case where patients, parents or guardians elect to opt out of data analysis.
结局指标
主要结局
Correlation between physiological parameters and G-forces during transport episode
时间窗: 12 months study period
Beat to beat, wave-form data from physiological parameters of heart rate, oxygen saturations and invasive arterial blood pressure measured during transport will provide a set of continuous data outputs. Calculating the correlation coefficient will indicate the strength of relationship between physiological parameters and the experienced G-forces with the aim of answering two questions: 1. Do G-forces (the acceleration and deceleration forces) experienced by being in a moving ambulance, affect the stability of patient observations - heart rate, blood pressure and oxygen saturations. 2. Do G-forces experienced by being in a moving ambulance, affect the delivery of vasoactive/inotropic drug infusions which in turn affects the stability of observations.
次要结局
未报告次要终点