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临床试验/NCT03499132
NCT03499132已完成不适用

Influence of Different Anesthetic Procedures on Sleep Disorder Breathing in Adult Patients Undergoing Elective Surgery

St. Anne's University Hospital Brno, Czech Republic1 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2018年3月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
90
试验地点
1
主要终点
Apnea-hypopnea index change

研究概览

简要总结

Obstructive sleep apnea (OSA) is a common form of sleep disordered breathing characterized by partial or complete upper airway obstructions during sleep. OSA is associated with major comorbidities and perioperative complications. These complications are caused not only by the OSA itself, but also by exacerbations of this syndrome during the perioperative period (1). Benzodiazepines, volatile anesthetics and opioids may lead to lower hypoxia and hypercapnia sensitivity and may cause respiratory depression (2-5). Therefore, preference of neuraxial blockades and avoidance of opioids has been suggested for patients with OSA (6). However, there is still lack of evidence to evaluate the effects of various anesthesia procedures on OSA (6,7). We hypothesize different anesthetic procedures will have different effect on OSA exacerbations in the postoperative period. Accordingly, the aim of this study is to compare the number of sleep disordered breathing episodes in the postoperative period in patients with different anesthetic procedures.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 100 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • elective orthopedic surgery

排除标准

  • already diagnosed sleep disorder breathing
  • continuous positive airway pressure therapy
  • tracheostomy
  • American Society of Anesthesiologists class IV-V

结局指标

主要结局

Apnea-hypopnea index change

时间窗: 4 nights after surgery

Changes (post-pre) in apnea-hypopnea index 4 nights post surgery

次要结局

未报告次要终点

研究者

发起方
St. Anne's University Hospital Brno, Czech Republic
申办方类型
Other
责任方
Principal Investigator
主要研究者

Ivan Cundrle

M.D., Ph.D.

St. Anne's University Hospital Brno, Czech Republic

研究点 (1)

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