Cognitive-motor Training on Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Gait variability
研究概览
简要总结
Literature reviews showed the cognitive-motor training that combines cognitive tasks may enhance cognitive functions more effectively than individual interventions. Stepping-based cognitive-motor training has been shown to improve cognitive functions, balance, and gait performance in older adults. However, there is insufficient research evidence on the impact and correlation of this training mode on the walking ability, executive functions, and brain activity changes in people with PD. Therefore, this study is designed to investigate the effects of stepping-based cognitive-motor training on the walking ability, executive functions, and brain activity in people with PD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnoses of idiopathic Parkinson disease
- •Stable dopaminergic medicine ≥ 2 weeks
- •Able to walk 10 meters without aid
- •Mini-Mental Status Examination ≥ 24 points
- •No uncorrected visual or auditory disorders
- •Education at least junior high school
- •No other disease may affect balance
排除标准
- •Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
- •History of brain surgery (e.g. deep brain stimulation)
结局指标
主要结局
Gait variability
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure the coefficient of variation (CV). The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean \* 100%
Gait speed
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure gait speed
Step length
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure step length
Step width
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure step width
Single support time
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure single support time
Double support time
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure double support time
Frontal Assessment Battery
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
The score ranged from 0 to 18. Higher scores show better executive function.
Stroop color and word test
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Record numbers of corrected color words which the subject responds within 45 sec.
Digit span test
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Digit span test contain forward and backward part. Scores of forward digit span ranges from 0 to 16. Score of backward digit span ranges from 0 to 14. Higher scores indicate better executive function.
Event-related potential - N2
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Event-related potential - P300
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Go/Nogo test
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Behavioral test during measuring electroencephalography.
Trail making test
时间窗: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Trail making test contain part A and part B. Faster completing the test indicates better executive function.
次要结局
- Mini-Balance Evaluation Systems Test(Before and after 8 weeks of intervention, as well as 4 weeks after intervention)
- Montreal Cognitive Assessment(Before and after 8 weeks of intervention, as well as 4 weeks after intervention)
- Timed up and go test(Before and after 8 weeks of intervention, as well as 4 weeks after intervention)
- Parkinson Disease Questionnaire(Before and after 8 weeks of intervention, as well as 4 weeks after intervention)
研究者
Yea-Ru Yang
Professor
National Yang Ming Chiao Tung University