Adding L-carnitine in Clomiphene Resistant Pco Improves the Quality of Ovulation and the Pregnancy Outcome,a Randomized Clinical Trial
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 157
- 主要终点
- ovulation induction
研究概览
简要总结
Adding L-carnitine is more successful than clomiphene as a first line therapy for ovulation induction in women with clomiphene resistant PCOS
详细描述
Patients younger than 35 years, presenting with primary or secondary infertility following regular intercourse for at least 1 year and diagnosed with PCO according to Rotterdam's criteria who had received five unsuccessful clomiphene citrate-timed intercourse stimulation cycles were included.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients younger than 35 years, presenting with primary or secondary infertility following regular intercourse for at least 1 year and diagnosed with PCO according to Rotterdam's criteria who had received five unsuccessful clomiphene citrate-timed intercourse stimulation cycles were included. The diagnosis was based on a complete history taking, physical examination and a paper documented complete infertility work-up within the previous 6 months, either conducted within the setting of the hospital or at a licensed infertility management clinic.
排除标准
- •age more than 40 years,
- •tubal,uterine or male factor infertility
研究组 & 干预措施
l-carnitine
adding 3gm l-carnitine from day 1 to day 12 of induced the menstrual cycle by 50 mg clomiphene
干预措施: l-carnitine (Drug)
结局指标
主要结局
ovulation induction
时间窗: 0ne year
is to study the efficacy of l-carnitine in inducing ovulation in clomiphene resistant pco
次要结局
- pregnancy(0ne year)
研究者
alaa eldeen mahmoud ismail
assistant professor
Woman's Health University Hospital, Egypt