Pressure-dependent Changes in Hematocrit and Plasma Volume During Anesthesia
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- The magnitude and dynamics of the decrease in hematocrit during anesthesia induction
研究概览
简要总结
The arterial blood pressure affects the ratio between filtration and reabsorption of fluids in the circulating blood volume and thereby the hematocrit. During induction of anesthesia blood pressure, hemoglobin level and hematocrit decreases. The aim of the study is to evaluate weather a maintained blood pressure with norepinephrine during anesthesia induction reduces the decrease in hematocrit.
详细描述
24 patients scheduled for coronary artery bypass surgery will be included and randomized to receive either norepinephrine in the dose needed to maintain pre-anesthesia blood pressure or to a control group and receive norepinephrine only if mean arterial pressure decreases below 60 mmHg. Arterial blood gas will be analysed every ten minutes. Equal anesthesia in both groups will be monitored. No fluids will be infused. Noninvasive continuous hemoglobin measurement (SpHb) will be measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective coronary artery surgery patients
排除标准
- •Age under 18 years
- •untreated hypertension
- •a reduced left ventricular systolic ejection fraction of 45 % or less
- •diabetes mellitus
- •former stroke and/or a known carotid artery stenosis.
研究组 & 干预措施
Maintained blood pressure
Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
干预措施: Maintained blood pressure (Procedure)
Maintained blood pressure
Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
干预措施: Norepinephrine (Drug)
结局指标
主要结局
The magnitude and dynamics of the decrease in hematocrit during anesthesia induction
时间窗: 70 minutes from anesthesia induction
次要结局
- Reduced hematocrit decrease by vasopressor infusion maintained blood pressure(70 minutes from anesthesia induction)
研究者
Tor Damén
MD
Sahlgrenska University Hospital, Sweden