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临床试验/CTRI/2026/03/105147
CTRI/2026/03/105147尚未招募1/2 期

Outcomes of Ventral Inlay Buccal Mucosal Graft Urethroplasty vs Dorsal Onlay Buccal Mucosal Graft Urethroplasty in Female Urethral Stricture Disease: A Randomised Control Trial

Department of Urology1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2026年3月10日最近更新:

试验速览

阶段
1/2 期
状态
尚未招募
入组人数
30
试验地点
1

研究概览

简要总结

Female Urethral Stricture is a rare condition with incidence of 4-13% in females with bladder outlet obstruction. Various techniques of repair have beed implimented for treatment of Female Urethral Stricture with Buccal Mucosal Graft Urethroplasty having most successful outcomes.

Female urethral stricture disease remains a challenging condition to treat, with advances in buccal mucosal graft urethroplasty have significantly improved patient outcomes. The dorsal onlay technique is widely regarded as the most effective approach, particularly for long or complex strictures, while ventral inlay and vaginal grafts provide alternative solutions.

Despite the growing body of research on urethral stricture management, several critical gaps exist in the current literature regarding ventral inlay vs. dorsal onlay urethroplasty in female patients. Limited Direct Comparison studies are available; while individual success rates for both ventral inlay and dorsal onlay urethroplasty have been reported, no comprehensive prospective studies directly comparing the two techniques in females exist.

The present research aims to provide valuable insights into the optimal surgical management for female urethral stricture, ultimately improving patient care and clinical outcomes.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant and Investigator Blinded

入排标准

年龄范围
18.00 Year(s) 至 70.00 Year(s)(—)
性别
Female

入选标准

  • IPSS(International Prostate Symptom Score) score more than 7
  • Maximun Urine Flow Rate(Qmax) less than 12 ml/min
  • Post Void Residue(assessed Ultrasonographically) more than one-third of Prevoid volume.
  • Inability/difficulty in calibration with 12 Fr Per Urethral catheter
  • Cystourethroscopy with 12 Fr Cysotoscope to demonstrate Urethral Stricture.

排除标准

  • More than Grade I Pelvic Organ prolapse
  • Patients with Focal neurological deficit
  • Pregnant patients
  • Recurrent urethral stricture disease.

研究者

申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Tejas Chandrakant Chaudhari

All India Institute of Medical Sciences, Bathinda

研究点 (1)

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