Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Measurement of white blood cell and its differential counts such as neutrophils (%), basophils (%)
研究概览
简要总结
Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages.
详细描述
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer's disease (AD). Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants including those dropped out (5%) were screened and enrolled. The selected participants were treated as a single group without randomization. Evaluated the association between total and differential white blood cell (WBC) counts and AD risk at individual levels after 4 weeks of H2 gas inhalation treatment. Furthermore, evaluation of dementia-related biomarkers such as beta-site APP cleaving enzyme 1 (BACE-1), amyloid beta (Aβ), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor A (VEGF-A), T-tau, monocyte chemotactic protein-1 (MCP-1), and inflammatory cytokines (interleukin-6).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
盲法说明
Before and after of treatment in single group
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ranges 40-70 years
- •Healthy participants
- •Patients who are willing or able to follow the doctor's instructions
- •Fully understand the purpose and procedure of this clinical trial
排除标准
- •Participants excluded those who have any disease
- •Pregnant and lactating women
研究组 & 干预措施
Single arm
Single group treatment
干预措施: H2 gas inhalation (Other)
结局指标
主要结局
Measurement of white blood cell and its differential counts such as neutrophils (%), basophils (%)
时间窗: 4 weeks
4 weeks treatment of H2 gas inhalation in community dwelling adults of various ages
Measurement of oxidative stress markers such as reactive oxygen species (µM), and nitric oxide (µM)
时间窗: 4 weeks
4 weeks treatment of H2 gas inhalation in community dwelling adults of various ages
次要结局
- Measurement of dementia biomarkers such as brain-derived neurotrophic factor amyloid beta (Aβ (pg/mL))(4 weeks)
- Measurement of dementia biomarkers such as brain-derived neurotrophic factor (BDNF ng/mL)(4 weeks)
- Measurement of inflammatory markers such as interleukin 6 (pg/mL)(4 weeks)
研究者
Kyu Jae Lee
Professor
Wonju Severance Christian Hospital