AVF Volume Blood Flow Reduction in HD Patients with Chronic Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 86
- 试验地点
- 1
- 主要终点
- Left ventricular ejection fraction
研究概览
简要总结
Heart failure with preserved / high cardiac output is a well-known syndrome in patients with high-flow arteriovenous fistula (AVF). However, the threshold for classifying an AVF as high-flow is currently undefined. Cardio-fistular recirculation (CFR) is often used as a criterion, with values greater than 25-30% considered cardiotoxic and associated with adverse outcomes. Additionally, CFR is one of the few easily modifiable risk factors through surgical reduction of AVF volume blood flow (Qa).
The study aimed to evaluate the extent of involution of heart structural and functional changes following Qa reduction in patients with heart failure and CFR > 25%.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed informed consent
- •age > 18 years
- •Native arteriovenous fistula or vascular graft
- •Heart failure with preserved CO (NYHA I-IV )
- •Cardio-fistula recirculation ≥ 25%
- •eKt/V > 1.2
- •Absence of arrhythmias (except grade I AV block)
- •Absence of valvular disease (except mitral regurgitation I-II)
- •Arteriovenous fistula blood flow reduction surgery
排除标准
- •Kidney transplantation
- •Conversion of vascular access to central venous catheter
- •Withdrawal of informed consent
结局指标
主要结局
Left ventricular ejection fraction
时间窗: Before and at 6 months after surgery
Estimated pulmonary artery pressure
时间窗: Before and at 6 months after surgery
E/A ratio
时间窗: Before and at 6 months after surgery
次要结局
- NT-proBNP serum concentration(Before and at 6 months after surgery)
研究者
Alexey Zulkarnaev
Leading Researcher
Moscow Regional Research and Clinical Institute (MONIKI)