Impact of Oropharyngeal Microorganism Colonization on the Peristomal Infection After Percutaneous Endoscopic Gastrostomy and the Effect of Tailored Antibiotics Prophylaxis
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Peristomal wound infection
研究概览
简要总结
Tailored antibiotic prophylaxis according to the individual throat swab culture could reduce the peristomal infection rate
详细描述
Past know-how:
Antibiotic prophylaxis has been shown to be effective to reduce peristomal infection.[9-11] The penicillin-or cephalosporin-based antibiotic prophylaxis are usually used with similar efficacy.[12] EuropeanSociety of Gastrointestinal Endoscopy (ESGE) guideline recommend that a single dose of intravenous cephalosporin orpenicillin as preparation before PEG.[17] The updated practice guidelines of American Society for Gastrointestinal Endoscopy (ASGE) and British Society of Gastroenterology (BSG) also recommend cefazolin or cefuroxime as prophylactic antibiotics.[18-19]
Question:
Is the 1st or 2nd generation cephalosporin is adequate as prophylactic antibiotics for percutaneous endoscopic gastrostomy (PEG)?
Preliminary results:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patients who receive PEG by pull method in our hospital, a tertiary transferring center, will be included
排除标准
- •The exclusion criteria for entry are inability to place the gastrostomy for technical reasons, such as oropharyngeal deformity or esophageal stricture. The patients who receive PEG by percutaneous push method will be excluded. The patients will be also excluded if active infection and fever are identified, and the PEG is delayed until the infection is brought under control.
研究组 & 干预措施
Cefuroxime group
Use the cefuroxime as prophylactic antiobiotics, according to the clinical guideline.
干预措施: cefuroxime (Drug)
Tailored antibiotics group
Tailored antibiotic is selected according to the patient's oropharyngeal microorganisms.
干预措施: Tailored antibiotic (Drug)
结局指标
主要结局
Peristomal wound infection
时间窗: Two weeks after operation of PEG
次要结局
未报告次要终点