Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- vecuronium requirements during neohepatic phase
研究概览
简要总结
The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may also be different according to the preoperative hepatic function as measured by MELD score during prehepatic phase, or graft to recipient body weight ratio (GRWR) during neohepatic phase. Therefore, the investigators are trying to investigate the difference of vecuronium requirements according to the phase of surgery or MELD score, GRWR.
详细描述
The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may by further reduced during anhepatic phase of liver transplantation. And the requirements may be increased as the graft functions during neohepatic phase.
We also postulated that the requirements may be different according to the preoperative hepatic function during preanhepatic phase, and according to the graft to recipient body weight ratio (GRWR) during neohepatic phase.
Therefore, we are trying to investigate the difference of vecuronium requirements according to the phase of surgery, MELD score, GRWR.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing elective living donor liver transplantation
排除标准
- •patients who can not undergo train-of-four test due to central or peripheral neuromuscular disease.
- •patients with severe cardiopulmonary diseases.
- •patients who received transfusion with more than 10 units of packed red blood cells.
- •primary non-functioning graft immediately after reperfusion of the graft.
- •patients who administered drugs that influences the metabolism of vecuronium (such as anticonvulsant: phenytoin, carbamazepine, primidone, sodium valproate)
- •patients undergoing cadaver donor liver transplantation
结局指标
主要结局
vecuronium requirements during neohepatic phase
时间窗: during neohepatic phase of liver transplantation
total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during neohepatic phase
vecuronium requirements during preanhepatic phase
时间窗: during prehepatic phase of liver transplantation
total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during preanhepatic phase
vecuronium requirements during anhepatic phase
时间窗: during anhepatic phase of liver transplantation
total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during anhepatic phase
次要结局
未报告次要终点
研究者
Gaab Soo Kim
Professor
Samsung Medical Center