HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- HOXB7 Expression
研究概览
简要总结
This pilot, multicenter, interventional study investigates the expression of HOXB7 and its associated molecular pathway in lung tissue and blood-derived exosomes from patients with pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF). Using RNA sequencing (RNA-Seq) and proteomic analysis via mass spectrometry (MS), the study aims to identify tissue and circulating biomarkers associated with fibrosis progression. The study compares different biopsy techniques (surgical vs. transbronchial cryobiopsy) and also includes a control group of patients undergoing lung resection for non-fibrotic conditions.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 to 80 with clinical suspicion of pulmonary fibrosis
- •Availability of fresh lung tissue from biopsy or lung explant
- •Signed informed consent for research use of biological material and data
排除标准
- •- Refusal to sign informed consent
研究组 & 干预措施
Controls
Patients undergoing lung lobectomy for lung cancer suspicion.
干预措施: Biopsy (Procedure)
Cases
Patients undergoing surgical lung biopsy/criobiopsy for clinical purpose in the diagnostic work-up of ILD.
干预措施: Biopsy (Procedure)
结局指标
主要结局
HOXB7 Expression
时间窗: Baseline
HOXB7 gene and protein expression in lung biopsy samples
次要结局
- Assessment of RNA content(Baseline)
- Assessment of proteins content(Baseline)
研究者
Roberto Tonelli
Principal investigator
University of Modena and Reggio Emilia