The Performance of the APPY1 Test in the Evaluation of Possible Acute Appendicitis in Children, Adolescents, and Young Adults Presenting to the Emergency Department
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,201
- 试验地点
- 29
- 主要终点
- Sensitivity, Specificity, Negative and Positive Predictive Value
研究概览
简要总结
This study will consist of a brief interaction with the subject or parent or guardian to obtain consent, collect a blood sample, medical history, and physical examination of those who meet the inclusion criteria. The blood sample will be tested for the WBC value, as well as processed into plasma in order to compute the APPY1 Test result, which is based on a combination of the WBC value and the plasma MRP 8/14 and CRP concentrations received from the APPY1 Test cassette. There will be a 2-week (14 days +/- 3) follow-up telephone call for those subjects that were discharged from the ED without an appendectomy or diagnosis of acute appendicitis. Use of the APPY1 Test to help identify low risk patients could significantly reduce the use of CT scans in diagnosis of AA, thereby reducing the exposure to ionizing radiation in children, adolescents, and young adults.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •2 to 20 years old (up until the 21st birthday),
- •Right lower quadrant or poorly localized abdominal pain, or tenderness that includes the right lower quadrant, and/or other features including, but not limited to, nausea, vomiting, and/or anorexia, requiring acute appendicitis to be added to the differential,
- •Onset of abdominal pain within 72 hours or less,
- •Patients of either gender may participate and,
- •Patient or accompanying parent or guardian is able to provide informed consent.
排除标准
- •History includes prior appendectomy,
- •Subjects whose presentation history and physical examination place them at such high risk of acute appendicitis that it would be clinically reasonable to proceed with exploratory laparotomy and/or appendectomy without advanced imaging,
- •Treatment with any immunosuppressive medication or chemotherapeutic agents within 28 days, or systemic steroids (oral or intravenous) within 14 days,
- •History of end-stage, metastatic cancer or an active immune disorder,
- •History includes abdominal trauma or invasive abdominal procedures/surgery within the previous two weeks,
- •Patients who have received diagnostic imaging (CT, MRI, or US) for abdominal pain in the previous two weeks,
- •Patients with report of abdominal pain greater than 72 hours,
- •History of active bleeding disorder, which may complicate phlebotomy or placement of peripheral IV catheter,
- •Participation in a research study within the previous 30 days,
- •Prisoners of an adult or juvenile detention center, and
- •Subject, parent or guardian unable to provide informed consent.
结局指标
主要结局
Sensitivity, Specificity, Negative and Positive Predictive Value
时间窗: Upon 3rd party review of data
95% confidence intervals on Sensitivity and Specificity
次要结局
- CT utilization(Upon 3rd party review of data)