Multisensory Rehabilitation of Vision Loss After Cortical Damage
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
研究概览
简要总结
Damage to visual cortex on one side of the brain frequently produces a profound and permanent blindness in contralesional space (hemianopia), a debilitating condition that causes enormous suffering for patients and their families.
详细描述
The over-arching objective of the current proposal is to evaluate the functional recovery of vision in hemianopic (blindness in one hemifield) and quadrantanopic (blindness in one quadrant) patients engaged with a multisensory training paradigm. This will pave the way for clinical trials in which this simple, non-invasive training paradigm can be developed for therapeutic use to treat blindness resulting from cortical damage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients will be recruited from the local subject population hospitalized/seen by Ophthalmology, Neurosurgery, and Neurology at Atrium Health Wake Forest Baptist
- •diagnosis of stable homonymous hemianopia (>4 weeks) with absence of hemineglect
- •a lesion encompassing at least primary visual cortex but sparing parietal cortex, to include lesions caused by an ischemic or hemorrhagic stroke or post-surgical changes due to an oncologic or non-oncologic tumor
- •normal or correctable auditory and cognitive function
- •willingness to participate in the three-month program
- •ability to perform visual discriminations in their intact field
- •life expectancy ≥12 months
排除标准
- •diagnosis of an unstable homonymous hemianopia and/or with hemineglect,
- •Abnormal or uncorrectable auditory and cognitive function
- •unwillingness to participate in the program
- •inability to perform the visual testing in their intact field
- •life expectancy < 12 months
- •Any other condition that would compromise their ability to complete the study.
研究组 & 干预措施
multisensory training
At the completion of this initial intervention (12 research sessions + clinical visits at the time of the first and last session), participants will receive a second kinetic visual field test and a 30-2 visual field test to measure any changes according to the clinical standard.
Two additional follow-up procedures are scheduled for participants identified as showing visual recovery after the initial intervention.
Three months after completing the initial treatment, participants will have an additional research visit. If testing during this visit reveals that vision has degraded from the initial series, participants will be scheduled for 2-5 additional research visits (with testing and training) to reinstate recovery with re-intervention.
干预措施: Multisensory Rehabilitation (Behavioral)