NCT02012244已完成不适用
Effects of Postoperative Pain Management on Immune Function After Laparoscopic Resection of Colorectal Cancer
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- NK cell activity
研究概览
简要总结
The purpose of this study is to compare postoperative immune function (e.g. NK cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA class I-III
- •20-80 years old
- •elective laparoscopic colorectal surgery for cancer
排除标准
- •drug allergy
- •significant renal or hepatic impairment
- •sign of infection
研究组 & 干预措施
fentanyl-based analgesia
Experimental
fentanyl intravenous patient-controlled analgesia + additional pethidine
干预措施: fentanyl-based analgesia (Drug)
local anesthetic wound infiltration-based anlagesia
Experimental
continuous wound inflitration with ropivacaine + tramadol intravenous patient-controlled analgesia + additional ketorolac or propacetamol
干预措施: local anesthetic wound infiltration-based anlagesia (Drug)
结局指标
主要结局
NK cell activity
时间窗: 48 hours
NK cell activity : preoperation, POD 1, POD 2
IL-2
时间窗: 48 hours
IL-2 level : preoperation, POD 1, POD 2
次要结局
- Complication and recurrence(1 year)
研究者
So Yeon Kim
Assistant professor
Severance Hospital
研究点 (1)
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