A Role for Light Therapy at Immediate Recovery From Short Duration Ambulatory Anesthesia to Prevent Dysregulation of Circadian Rest-Activity Rhythm in Patients Submitted to Colonoscopy.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 360
- 试验地点
- 12
- 主要终点
- Modification of on parametric analysis of circadian rhythm of rest-activity post anesthesia as compared to reference period (within factor) ; between factor : light intensity group
研究概览
简要总结
We previously evidenced in both animal models and patients that a short duration ambulatory anesthesia impacts the circadian rest-activity biological rhythm, at least during the first 3 days. The light is the main, natural synchronisateur, of the biological cerebral clock, and is used as therapeutics in chronic disturbances of the circadian rest activity rhythm and of the sleep (Alzheimer disease for example). We would like to test for a simple and safe strategy to prevent such a long-lasting effect of anesthesia on biological clock:the increase of the light intensity at a still physiological level during the initial phase of recovery from anesthesia by using a particular artificial light of color spectrum similar to natural sun daylight.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I & II
- •ambulatory anesthesia for colonoscopy on Monday or Tuesday
- •social security
排除标准
- •treatment for cancer
- •hypnotics, beta-bloquers
- •pregnancy
- •legal supervision
- •trans 5 meridian travel in the last two months
结局指标
主要结局
Modification of on parametric analysis of circadian rhythm of rest-activity post anesthesia as compared to reference period (within factor) ; between factor : light intensity group
时间窗: Within the first 5 days after anesthesia
次要结局
- Influence of gene period 3 phenotype on the effect of anesthesia(Blood sample taken the day of the anesthesia)