Multicentic Retrospective Evaluation of Risks in Mammary Carcinoma Relapse in Patients With Mammary Reconstruction and Autologous Fat Grafting
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 6,510
- 试验地点
- 1
- 主要终点
- Oncological safety of autologous fat grafting
研究概览
简要总结
Autologous fat grafting, also known as lipofilling, is a surgical technique consisting in the processing and transfer of adipose tissue from one area in our organism (hips, thighs) to region which in need of reconstructive and aesthetic correction. The technique is frequently used after radical or conservative mammary surgery, aiming to achieve better aesthetic results, reduce pain induced by both surgery and radiotherapy. The scientific community was widely involved in the debate regarding the use of mesenchymal/stem cells in a patient with high risk of tumor progression due to their elevated proliferative profile. This study aims to retrospectively evaluate the oncological safety in the use of lipofilling in patients who underwent oncological and reconstructive treatment in our Institute.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •breast carcinoma (any histological type, carcinoma in situ included) treated with radical or conservative surgery
- •group treated with lipofilling and group which didnt receive lipofilling
- •timing: retrospective evaluation of cases form 2006 to 2016, with a minimum of two year follow up
排除标准
- •neoplasie different from infiltrating and in sutu breast carcinoma
- •in situ lobular carcinoma
- •patients with breast carcinoma and metastasis
- •lipofilling procedure used before the oncological treatment for breast carcinoma
结局指标
主要结局
Oncological safety of autologous fat grafting
时间窗: Two years
Percentage of disease relapse in loco
次要结局
- Establishment of timing in disease relapse(Two years)
- Establish overall survival rate in experimental and control groups(Two years)
- Establish the distribution in disease relapses(Two years)
研究者
Andrea Lisa
MD
Humanitas Clinical and Research Center
