Pathophysiology of Orthostatic Intolerance
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 260
- 试验地点
- 1
- 主要终点
- Physiological abnormalities in orthostatic intolerance
研究概览
简要总结
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.
详细描述
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.
This is not a clinical trial in the classical sense, but an omnibus protocol to allow for disntinct and personalized pathophysiological testing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Orthostatic intolerance
排除标准
- •Inability or unwillingness to give informed consent
研究组 & 干预措施
Patients
Patients with orthostatic intolerance
干预措施: DAXOR (Radiation)
Patients
Patients with orthostatic intolerance
干预措施: QSweat (Procedure)
Patients
Patients with orthostatic intolerance
干预措施: Intrinsic Heart Rate (Drug)
Healthy Control Subjects
Healthy subjects to determine "normal" response
干预措施: DAXOR (Radiation)
Healthy Control Subjects
Healthy subjects to determine "normal" response
干预措施: QSweat (Procedure)
Healthy Control Subjects
Healthy subjects to determine "normal" response
干预措施: Intrinsic Heart Rate (Drug)
结局指标
主要结局
Physiological abnormalities in orthostatic intolerance
时间窗: 1 day
varied metrics used here
次要结局
- blood volume(1 day)
- intrinsic heart rate(1 hour)
- quantitative sweat testing(2 hours)
- residual sympathetic function after pharmacological autonomic blockade(3 hours)
- norepinephrine spillover(3 hours)
研究者
Satish R. Raj
Assistant Professor of Medicine & Pharmacology
Vanderbilt University Medical Center