Tn-Miner: Technology for the Discovery of Tumor-specific Glycopeptide Immunotherapy Targets.
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 36
- 试验地点
- 4
- 主要终点
- Discovery of new, tumor-specific, glycopeptide epitopes.
研究概览
简要总结
The goal of this interventional, prospective research on human bodily material is to discover new, cancer-specific molecular structures (i.e. glycopeptides) within surgically removed, estrogen receptor positive breast cancer tumors.
The main goal it aims to achieve is:
To discover tumor-specific targets, that allow the use of very potent immunotherapeutic drugs as treatment for solid tumors, such as estrogen receptor positive breast cancer. These new targets are very specific for cancer cells, meaning that virtually no healthy cells should be attacked by the treatment, resulting in less side effects.
Participants will undergo standard of care treatment, comprising surgical removal of the breast tumor. Part of these tissues will be used for this clinical research.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Minimally 18 years old
- •Diagnosed with estrogen-receptor positive breast cancer
- •This must be a primary tumor
排除标准
- •Younger than 18 years old
- •Previous history of other tumors
结局指标
主要结局
Discovery of new, tumor-specific, glycopeptide epitopes.
时间窗: The patients are only involved during their standard of care surgery (one day). The discovered epitopes will not be shared with enrolled patients.
The discovery of new antigens, comprising both glycan and peptide (=glycopeptide), on the outside of the plasma membrane of the breast cancer cells. These antigens should be absent on healthy cells. These new, glycopeptide antigens can be used as target for immunotherapeutics against cancer.
次要结局
未报告次要终点